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translocations or amplifications along with the genomic alterations now current in the first CLL, but lack the prevalent mutations observed in Major DLBCL indicating which they might correspond to a unique biological class.

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48 These translocations may well occur inside the context of advanced karyo types. The most common rearrangements MBL77 entail 13q14, with many associates, and also the IGH locus. The genes mostly rearranged with IGH are BCL2